abstract：:This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1 Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 kDa, AS160) and their roles in controlling skeletal muscle glucose transport in response to the independent and combined effects of insulin and exerc...

journal_title：Diabetologia

authors： Cartee GD

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. METHODS:We studied 2,603 and 2,386 Europeans from the Botnia study and Malmö Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-u...

journal_title：Diabetologia

authors： Alyass A,Almgren P,Akerlund M,Dushoff J,Isomaa B,Nilsson P,Tuomi T,Lyssenko V,Groop L,Meyre D

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...

journal_title：Diabetologia

authors： Lin HC,Wang CH,Tsai FJ,Hwang KP,Chen W,Lin CC,Li TC

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

journal_title：Diabetologia

authors： Premilovac D,Richards SM,Rattigan S,Keske MA

更新日期：2014-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...

journal_title：Diabetologia

authors： Price AH,Welsh P,Weir CJ,Feinkohl I,Robertson CM,Morling JR,McLachlan S,Strachan MW,Sattar N,Price JF

更新日期：2014-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cel...

journal_title：Diabetologia

authors： Vázquez P,Robles AM,de Pablo F,Hernández-Sánchez C

更新日期：2014-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...

journal_title：Diabetologia

authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

更新日期：2014-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although obesity is a major risk factor for diabetes, little is known about weight gain trajectories across adulthood, and whether they are differentially associated with metabolic markers of diabetes. METHODS:We used fasting blood samples and longitudinal weight data for 5,436 adults (5,734 observatio...

journal_title：Diabetologia

authors： Gordon-Larsen P,Koehler E,Howard AG,Paynter L,Thompson AL,Adair LS,Mayer-Davis EJ,Zhang B,Popkin BM,Herring AH

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Subtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of developing diabetes. Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in G...

journal_title：Diabetologia

authors： Bender C,Schlosser M,Christen U,Ziegler AG,Achenbach P

更新日期：2014-09-01 00:00:00

abstract：:Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha ce...

journal_title：Diabetologia

authors： Rorsman P,Ramracheya R,Rorsman NJ,Zhang Q

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. METHODS:In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing allele...

journal_title：Diabetologia

authors： Zhu J,Zong G,Lu L,Gan W,Ji L,Hu R,Ye X,Sun L,Loos RJ,Li H,Lin X

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) have been shown to abrogate in vitro the proinflammatory response in type 1 diabetes. The mechanism involves paracrine factors, which may include microvesicles (MVs). We evaluated whether MVs derived from heterologous bone-marrow MSCs exert an immunomodulatory effect on T c...

journal_title：Diabetologia

authors： Favaro E,Carpanetto A,Lamorte S,Fusco A,Caorsi C,Deregibus MC,Bruno S,Amoroso A,Giovarelli M,Porta M,Perin PC,Tetta C,Camussi G,Zanone MM

更新日期：2014-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...

journal_title：Diabetologia

authors： Hamilton DL,Findlay JA,Montagut G,Meakin PJ,Bestow D,Jalicy SM,Ashford ML

更新日期：2014-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...

journal_title：Diabetologia

authors： ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is...

journal_title：Diabetologia

authors： Ittner AA,Bertz J,Chan TY,van Eersel J,Polly P,Ittner LM

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regen...

journal_title：Diabetologia

authors： Fenzl A,Itariu BK,Kosi L,Fritzer-Szekeres M,Kautzky-Willer A,Stulnig TM,Kiefer FW

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to estimate the heritability of quantitative measures of glucose regulation obtained from a tolbutamide-modified frequently sampled IVGTT (t-FSIGT) and to correlate the heritability of the glucose-stimulated beta cell response to the tolbutamide-induced beta cell response. In a...

journal_title：Diabetologia

authors： Gjesing AP,Hornbak M,Allin KH,Ekstrøm CT,Urhammer SA,Eiberg H,Pedersen O,Hansen T

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...

journal_title：Diabetologia

authors： Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

更新日期：2014-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial cell (EC) damage is a key mechanism causing retinal microvascular injury in diabetes. Several microRNAs (miRNAs) have been found to regulate sirtuin 1 (SIRT1, which is involved in regulation of the cell cycle, survival and metabolism) in various tissues and disease states, but no studies hav...

journal_title：Diabetologia

authors： Mortuza R,Feng B,Chakrabarti S

更新日期：2014-05-01 00:00:00

abstract：:Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...

journal_title：Diabetologia

authors： Atkinson MA

更新日期：2014-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...

journal_title：Diabetologia

authors： Kallas-Koeman MM,Kong JM,Klinke JA,Butalia S,Lodha AK,Lim KI,Duan QM,Donovan LE

更新日期：2014-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although insulin resistance has been associated with accumulations of specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these concepts remain controversial. Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations ass...

journal_title：Diabetologia

authors： Holloway GP,Han XX,Jain SS,Bonen A,Chabowski A

更新日期：2014-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few studies have investigated the relationship between predefined dietary patterns and type 2 diabetes incidence; little is known about the generalisability of these associations. We aimed to assess the association between predefined dietary patterns and type 2 diabetes risk in European populations. ME...

journal_title：Diabetologia

authors： InterAct Consortium.

更新日期：2014-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Haffner SM

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A conce...

journal_title：Diabetologia

authors： Ley SH,Sun Q,Jimenez MC,Rexrode KM,Manson JE,Jensen MK,Rimm EB,Hu FB

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...

journal_title：Diabetologia

authors： Mezghenna K,Leroy J,Azay-Milhau J,Tousch D,Castex F,Gervais S,Delgado-Betancourt V,Gross R,Lajoix AD

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...

journal_title：Diabetologia

authors： Sluik D,Boeing H,Li K,Kaaks R,Johnsen NF,Tjønneland A,Arriola L,Barricarte A,Masala G,Grioni S,Tumino R,Ricceri F,Mattiello A,Spijkerman AM,van der A DL,Sluijs I,Franks PW,Nilsson PM,Orho-Melander M,Fhärm E,Roland

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...

journal_title：Diabetologia

authors： Barbosa-Sampaio HC,Liu B,Drynda R,Rodriguez de Ledesma AM,King AJ,Bowe JE,Malicet C,Iovanna JL,Jones PM,Persaud SJ,Muller DS

更新日期：2013-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to estimate absolute and relative mortality rates in patients with type 1 diabetes at the Steno Diabetes Centre relative to the general Danish background population. METHODS:Patients with type 1 diabetes (n = 4,821) were followed from 1 January 2002 until 1 January 2011, with ...

journal_title：Diabetologia

authors： Jørgensen ME,Almdal TP,Carstensen B

更新日期：2013-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

journal_title：Diabetologia

authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

更新日期：2013-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration. METHODS:Using prosp...

journal_title：Diabetologia

authors： Franceschini N,Haack K,Göring HH,Voruganti VS,Laston S,Almasy L,Lee ET,Best LG,Fabsitz RR,North KE,Maccluer JW,Meigs JB,Pankow JS,Cole SA

更新日期：2013-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

journal_title：Diabetologia

authors： Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

更新日期：2013-10-01 00:00:00

abstract：:There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...

journal_title：Diabetologia

authors： Stene LC,Gale EA

更新日期：2013-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Perinatal exposure to bisphenol A (BPA), a widely distributed environmental endocrine disruptor, is associated with insulin resistance and diabetes in offspring. The underlying molecular mechanisms could involve epigenetics, as adverse effects induced by environmental exposure in early life are suggeste...

journal_title：Diabetologia

authors： Ma Y,Xia W,Wang DQ,Wan YJ,Xu B,Chen X,Li YY,Xu SQ

更新日期：2013-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Studies have shown that dipeptidyl peptidase-4 (DPP4) inhibitors stimulate insulin secretion and increase beta cell mass in rodents. However, in these models hyperglycaemia has been induced early on in life and the treatment periods have been short. To explore the long-term effects of DPP4 inhibition on...

journal_title：Diabetologia

authors： Omar BA,Vikman J,Winzell MS,Voss U,Ekblad E,Foley JE,Ahrén B

更新日期：2013-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS:Data were retrieved from the Medical Birth Register of Sweden for wome...

journal_title：Diabetologia

authors： Mattsson K,Källén K,Longnecker MP,Rignell-Hydbom A,Rylander L

更新日期：2013-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

journal_title：Diabetologia

authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

更新日期：2013-07-01 00:00:00